The transcription factor TCF7L1 is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in skin tumorigenesis has not yet been defined. Through transcriptome profiling and combined gain- and loss-of-function studies, we identified LCN2 as a major downstream effector of TCF7L1 that drives tumor growth. Our findings establish a tumor-promoting role for TCF7L1 in skin and elucidate the mechanisms underlying its tumorigenic capacity.
Nudity in film is the presentation in a film of at least one person who is nudepartially nude or wearing less clothing than contemporary norms in some societies consider " modest ". Since the development of the medium, inclusion in films of any form of sexuality has been controversial, and in the case of most nude scenes has had to be justified as being part of the story, in the concept of "artistically justifiable nudity". In some cases nudity is itself the object of a film or is used in the development of the character of the subject.
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