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By convention, a contralateral breast cancer CBC is treated as a new primary tumor, independent of the first cancer BC1. Although there have been indications that the second tumor BC2 sometimes may represent a metastatic spread of BC1, this has never been conclusively shown. Ten CBC patients with detailed clinical information and available fresh frozen tumor tissue were studied.
After an initial diagnosis of breast cancer, the risk of contralateral breast cancer is approximately 0. Annual mammography is recommended to identify local recurrences and contralateral new primaries. Because the sensitivity of mammography tends to be lower in younger women, we conducted a retrospective review of the method of detection and pathologic stage of metachronous contralateral primary breast cancers according to age at diagnosis in a cohort of breast cancer patients.
Current Breast Cancer Reports. Accurate estimates of contralateral breast cancer CBC risk are necessary around the time a first breast cancer is diagnosed to aid surgical decision-making. This review will discuss the known risk factors for contralateral breast cancer CBC and present methods for calculating CBC risk that can be utilized when breast surgeons counsel patients. Recent studies that take into account important covariates in contralateral breast cancer risk, such as BRCA1 and BRCA2 mutation carrier status, family history, and systemic treatment, are further improving estimates of contralateral risk.
Contralateral breast cancer incidence did not appear associated with age, family history or characteristics of initial ductal carcinoma in situ DCISnor did it appear associated with factors that increase ipsilateral breast tumor recurrence. Few studies have examined the risk for contralateral breast cancer after DCIS, particularly in women treated with breast-conserving surgery. Further, little data exists on factors associates with contralateral breast cancer following DCIS.
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By Caroline Helwick November 15, Advertisement. Breast cancer is highly unlikely to develop in the contralateral breast of women treated for primary breast cancer, yet many women continue to fear it and undergo prophylactic mastectomies. Uyeno and colleagues documented the incidence of contralateral breast cancer and its impact on overall survival after mastectomy for unilateral breast cancer.
Cumulative contralateral breast cancer risks were calculated using the Kaplan-Meier product-limit method and were compared between groups using the log-rank test. Cox regression analysis was applied to assess the impact of the age at first breast cancer and the familial history stratified by mutation status. The cumulative risk of contralateral breast cancer 25 years after first breast cancer was Younger age at first breast cancer was associated with a higher risk of contralateral breast cancer.
Contralateral breast cancer is the most common second cancer in women with primary breast cancer. With increasing cure rates comes increasing concern about their long-term health. Radiation Epidemiology Branch REB investigators and collaborators from the Kaiser health maintenance organization have developed a retrospective cohort of about 7, breast cancer patients diagnosed since
Metachronous contralateral breast cancer CBC is defined as a tumour in the opposite breast which was diagnosed more than 6 months following the detection of the first cancer. We screened, for factors that might predict the risk of developing CBC, a cohort series of women who had invasive unilateral breast cancer, clinical stage I-IIIa and had been treated at Institut Curie Paris between and Two hundred and eighty two CBC had been diagnosed with a median follow-up of 80 months. The cumulative rate of CBC was 4.