Uci adult downs sydrome program

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Arch Neurol. These findings support the rationale for a more extensive study of the efficacy of acetylcholinesterase inhibitors in Down syndrome dementia. After age 35 years, virtually all individuals with DS have developed the neuropathologic characteristics of the disorder, although a smaller percentage undergo symptoms of cognitive decline.

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Children with Down syndrome have unique health care and developmental concerns that often require integrated services from a multitude of health care, social, and educational services. The clinic is not designed to replace the services of the primary care physician but rather to complement these services by providing supplementary medical care with an emphasis on preventive medicine and case management services. By collaborating with primary care physicians, Down syndrome specialists and community based support services we will help patients reach their potential and optimal health and development.

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Led by William Mobleywho took over the Department of Neuroscience at the University of California, San Diego, from the late Leon Thal, the new center plans to integrate treatment and therapy with academic research. Their cognition typically is impaired compared to people of the same age. The two diseases have much in common.

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The purpose of this study is to evaluate the accuracy of two machine learning classification algorithms, Decision Tree and Random Forest, when attempting to classify individuals who may be likely to suffer from Autism Spectrum Disorder. This study details the data cleaning and pre-processing steps taken to prepare the data-set for classification such as dealing with missing values, outlier removal, variable selection, and the partitioning of the data into training and testing subsets. It also walks through the validation and evaluation methods used when choosing the most appropriate models for each algorithm.

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DS-CTN will leverage research best practices and data collection to accelerate clinical trials and to deepen the knowledge about Down syndrome. While initially focused on adults, the network will expand over time to include adolescents and children. They will be patient-focused and enable the rapid enrollment of volunteers for industry and publicly funded clinical trials.

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Irvine, Calif. In the study, brain scans of adults with Down syndrome showed increased metabolic activity in the temporal cortex — the same region of the brain where Alzheimer's disease commonly develops. The researchers speculate that Alzheimer's may begin with a similar metabolic increase, because Down syndrome often leads to dementia during adulthood.

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Gerard Fobes, 45, participates in research at UCI looking at why people with Down syndrome are more likely to develop Alzheimer's disease and do so at younger ages. Gerard Fobes, 45, sits in his favorite chair in the living room of his parents' Newport Beach home. He spends a lot of time doing research on his computer.

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Interestingly, atherosclerosis and hypertension are atypical in DS with age, suggesting the lack of these vascular risk factors may be associated with reduced cerebrovascular pathology. CAA was observed with significantly higher frequencies in brains of individuals with DS compared to sporadic AD and controls. Atherosclerosis and arteriolosclerosis were rare in the cases with DS.

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The center will focus on understanding the biological basis of Down syndrome and developing therapies to reverse or eliminate difficulties with cognition, speech, sleep and late-life decline in neurological function experienced by people with Down syndrome. The center's mission, coupled with the scientific and clinical talent it has recruited, uniquely position it to understand and develop new treatments for the disorder. Preliminary results from Stanford researchers on a mouse model of Down syndrome suggest it may be possible to develop effective therapies for the disorder within the next few years. Because individuals with Down syndrome develop early-onset Alzheimer's disease, the research also may benefit Alzheimer's patients.

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